|Vladimir Bogdanov, PhD|
|Internal Medicine - Hematology/Oncology|
|Assistant Professor of Medicine|
|Vontz Center for Molecular Studies
P. O. Box 670508
Cincinnati OH 45267
The research currently underway in the Hemostasis Research Program, Division of Hematology/Oncology, focuses on two major areas spanning the fields of cardiovascular biology, cancer research, and post-transcriptional regulation of Tissue Factor (TF) expression.
The first area comprises the studies examining the biologic functions of TF splice variants in the vasculature, and their contribution to such disease states as cardiovascular thrombosis, malignant tumor progression, and their combination – a common occurrence in certain forms of cancer. The second area comprises the studies of post-transcriptional regulation of TF expression in peripheral blood mononuclear cells (PBMC), known to extensively utilize alternative splicing mechanisms to carry out a large variety of functions.
|Srinivasan R, Ozhegov E, van den Berg YW, Aronow BJ, Franco RS, Palascak MB, Fallon JT, Ruf W, Versteeg HH, Bogdanov VY. (2011) Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling. J Thromb Haemost. 9:2087-2096.|
|van den Berg YW, van den Hengel LG, Myers HR, Ayachi O, Jordanova E, Ruf W, Spek CA, Reitsma PH, Bogdanov VY, Versteeg HH. (2009) Alternatively spliced tissue factor induces angiogenesis through integrin ligation. Proc Natl Acad Sci U S A. 106:19497-19502.|
|Tardos JG, Eisenreich A, Deikus G, Bechhofer DH, Chandradas S, Zafar U, Rauch U, Bogdanov VY. (2008) SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost. 6:877-884.|
|Bogdanov VY, Kirk RI, Miller C, Hathcock JJ, Vele S, Gazdoiu M, Nemerson Y, Taubman MB. (2006) Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost. 4:158-167.|
|Bogdanov VY, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. (2003) Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 9:458-462.|