Immunology & Infectious Diseases

Bradley Britigan

Bradley Britigan, MD

Internal Medicine

Taylor Professor

Chairman, Department of Internal Medicine

Research Summary

Dr. Britigan is the Taylor Professor and Chairman of the Department of Internal Medicine. His research interests focus on the oxygen and iron metabolism of phagocytic cells and pathogenic organisms. Current research in his laboratory examines the ability of pyocyanin and other secretory products of Pseudomonas aeruginosa to contribute tissue injury via their ability to induce the formation of toxic oxygen-free radicals. He is also studying mechanisms of iron acquisition by pathogenic microorganisms such as Mycobacterium tuberculosis and Francisella tularensis. Additional work applies spin trapping in conjunction with electron paramagnetic resonance spectrometry to explore the nature of oxygen-centered free radicals that are produced by phagocytes and which play a critical role in the microbicidal function of these cells. His research is funded by the National Institutes of Health and the Department of Veterans Affairs.

Recent Publications

Afton, S.E., Caruso, J.A., Britigan, B.E., Qin, Z. Copper egress is induced by PMA in human THP-1 monocytic cell line. BioMetals (in press)

Pasula, R., Britigan, B.E., Turner, J. and Martin, W.J. II. Airway delivery of silica increases susceptibility to mycobacterial infection in mice J. Immunol. (in press)

Reszka, K.J., McGraw, D.W., and Britigan, B.E. Peroxidative metabolism of B2-agonists salbutamol and fenoterol and their analogs. Chem. Res. Toxicol. (in press)

Panmanee,W., Gonzalez,F., Witte,D. Vijay,P. Shankar,R, Britigan,B,E,, and Hassett,D.J. The peptidoglycan-associated lipoprotein, OprL, helps protect a Pseudomonas aeruginosa mutant devoid of the transactivator, OxyR, from hydrogen peroxide-mediated killing during planktonic and biofilm culture. J. Bacteriol.190:3658-3669, 2008

Wen, F., Brown, K.E., Britigan, B.E., and Schmidt, W.N. Hepatitis C Core Protein Inhibits Induction of Heme Oxygenase-1 and Sensitizes Hepatocytes to Cytotoxicity. Cell Biol. Toxicol.. 24:175-188, 2008

Reszka, K.J., and Britigan, B.E. Adriamycin inhibits oxidation of ABTS by a lactoperoxidase/H2O2 System: Antioxidant properties of anthracyclines.Arch.Biochem.Biophys. 466:164-171, 2007

 

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