Cardiovascular & Lipid Disorders

David Askew

Sean Davidson , PhD

Pathology & Lab Med-North

Professor

Research Summary

The overall aim of the lab is to understand the mechanisms by which the body protects itself from heart disease. We use mutagenesis and spectroscopic techniques to study the structure/function relationships of the proteins that comprise high density lipoproteins.

Recent Publications

Davidson WS, Silva RA, Chantepie S, Lagor WR, Chapman MJ, Kontush A. Proteomicanalysis of defined HDL subpopulations reveals particle-specific proteinclusters: relevance to antioxidative function. Arterioscler Thromb Vasc Biol.2009 Jun;29(6):870-6. Epub 2009 Mar 26. PubMed PMID: 19325143.

Tubb MR, Smith LE, Davidson WS. Purification of recombinant apolipoproteinsA-I and A-IV and efficient affinity tag cleavage by tobacco etch virus protease. J Lipid Res. 2009 Jul;50(7):1497-504. Epub 2009 Mar 24. PubMed PMID: 19318686;PubMed Central PMCID: PMC2694348.

Shen L, Tso P, Wang DQ, Woods SC, Davidson WS, Sakai R, Liu M. Up-regulationof apolipoprotein E by leptin in the hypothalamus of mice and rats. PhysiolBehav. 2009 Aug 4;98(1-2):223-8. Epub 2009 May 28. PubMed PMID: 19481557.

Silva RA, Huang R, Morris J, Fang J, Gracheva EO, Ren G, Kontush A, Jerome WG,Rye KA, Davidson WS. Structure of apolipoprotein A-I in spherical high densitylipoproteins of different sizes. Proc Natl Acad Sci U S A. 2008 Aug26;105(34):12176-81. Epub 2008 Aug 21. PubMed PMID: 18719128; PubMed CentralPMCID: PMC2527885.

Tubb MR, Silva RA, Fang J, Tso P, Davidson WS. A three-dimensional homologymodel of lipid-free apolipoprotein A-IV using cross-linking and massspectrometry. J Biol Chem. 2008 Jun 20;283(25):17314-23. Epub 2008 Apr 22. PubMedPMID: 18430727; PubMed Central PMCID: PMC2427326.

 

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