Hematologic & Oncogenic Disease

Zhongyun DongZhongyun Dong, MD, PhD

Internal Medicine-Hematology/Oncology

Associate Professor of Medicine

  • Vontz 1308
  • P.O. Box 670508
  • Cincinnati, Ohio 45267
  • (513)558-2176
  • dongzu@uc.edu

Research Summary:

Key words:
prostate cancer, cancer biology, cancer detection and therapy, androgen receptor, angiogenesis, animal model

Summary:
My laboratory investigates novel approaches and therapeutics for cancer detection and therapy, focusing mainly on prostate cancer. For cancer detection, in a joint effort with researchers from College of Engineering at UC, we are developing nano-devices that can detect metastasis and deliver therapeutic agents. For cancer therapy, in collaboration with researchers from the Computational Biology Core and Department of Pathology at UC, we are identifying and developing novel therapeutic small molecules targeting molecules and pathways critical for cancer growth, angiogenesis, and metastasis. The computer-aided drug design, molecular and animal imaging, and various molecular, biochemical, and biophysical tools and technologies are used in these studies. Moreover, the novel devices and therapeutics developed will be evaluated in cell culture and in animal tumor models.

Recent Publications:

Liu Y, Mo JQ, Hu Q, Boivin G, Levin L, Lu S, Yang D, Dong Z, Lu S. Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. Cancer Res. 2008 Aug 1;68(15):6396-406. PubMed PMID: 18676865.

Lee K, Liu Y, Mo JQ, Zhang J, Dong Z, Lu S. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. BMC Cancer. 2008 Jun 2;8:158. PubMed PMID: 18518979; PubMed Central PMCID: PMC2430719.

Wang D, Lu S, Dong Z. Regulation of TGF-beta1 gene transcription in human prostate cancer cells by nitric oxide. Prostate. 2007 Dec 1;67(16):1825-33. PubMed PMID: 17941092.

Lu S, Lee J, Revelo M, Wang X, Lu S, Dong Z. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Clin Cancer Res. 2007 Oct 1;13(19):5692-702. PubMed PMID: 17908958.

Lu S, Wang A, Lu S, Dong Z. A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells. Mol Cancer Ther. 2007 Jul;6(7):2057-64. PubMed PMID: 17620434.

Lee J, Wang A, Hu Q, Lu S, Dong Z. Adenovirus-mediated interferon-beta gene transfer inhibits angiogenesis in and progression of orthotopic tumors of human prostate cancer cells in nude mice. Int J Oncol. 2006 Dec;29(6):1405-12. PubMed PMID: 17088978.

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