Endocrinology, Diabetes & Metabolism

Silvia Obici, MD

Internal Medicine

Associate Professor of Medicine

Research Summary

Clinical Interests: Endocrinology and Metabolism Obesity and Diabetes

Research Interests: CNS control of energy metabolism and obesity. The endocannabinoid system and the control of energy homeostasis. Physical exercise and CNS control of energy metabolism.

Selected Publications

Chun-Min Lo, Silvana Obici, H Henry Dong, Michael Haas, Dawnwen Lou, Dae Hyun Kim,  Min Liu, David D’Alessio, Stephen C Woods, and Patrick Tso. Impaired Insulin Secretion and Enhanced Insulin Sensitivity in Cholecystokinin-Deficient Mice. Diabetes accepted May 2011

Kimberly A Krawczewski Carhuatanta, Giovanna Demuro, Matthias H. Tschöp, Paul T. Pfluger, Stephen C Benoit, and Silvana Obici. (2011) Voluntary Exercise Improves High-fat Diet-Induced Leptin Resistance Independent of Adiposity. Endocrinology In press in July

Hsuchou H, Kastin AJ, Tu H, Markadakis EN, Stone KP, Wang Y, Heymsfield SB, Chua SS Jr, Obici S, Magrisso IJ, Pan W. Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB. Peptides. 2011 Jul;32(7):1392-9. Epub 2011 May 17. PubMed PMID: 21616110; PubMed Central PMCID: PMC3137692.

Matej Bajzer, Massimiliano Olivieri, et al.  and Silvana Obici. CB1 Antagonism Enhances Glucose Utilization and Activates Brown Adipose Tissue in Diet-Induced Obese Mice. Accepted for publication in Diabetologia August 2011

Carmelo Quarta, Roberta Mazza, Silvana Obici, Renato Pasquali, and Uberto Pagotto. Endocannabinoids and Obesity. Trends in Molecular Medicine, accepted may 2011.

Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans" by Tong J., Mannea E., Aime P., Pfluger P., Chun-Xia Yi, Castaneda T., Davis H., Xue-Ying Ren, Pixley S., Benoit S., Julliard K., Woods CS, Horvath T., Sleeman M., D'Alessio DA, Obici S., Frank R, and Tschöp M..  Journal of Neuroscience, accepted for publication coming out in April 2011.

Tammy L. Kindel, Paulo J.F. Martins, Stephanie M. Yoder, Ronald J. Jandacek, Randy J. Seeley, David A. D’Alessio, Silvana Obici, Patrick Tso. (2010) Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. Obesity (Silver Spring) 2010 Oct 28.     (PMID 21030948)