Internal Medicine

William RidgwayWilliam Ridgway, MD

Director, Division of Immunology, Allergy and Rheumatology

Associate Professor of Medicine

Research Summary:

My major areas of investigative interest are autoimmunity, immunogenetics, T cells, autoimmune (Type I) diabetes and autoimmune liver disease (Primary biliary cirrhosis). I am the Principal Investigator on two N.I.H. grants, “The Pathogenesis of Autoimmunity in a Murine Model of Primary Biliary Cirrhosis” and "Immunogenetic Control of NOD CD4+ T cell Tolerance". Our goal is to determine the immunogenetic mechanisms of PBC-like autoimmune liver disease arising in the NOD.c3c4 mouse, and to dissect genetic control of loss of T cell tolerance in nonobese diabetic (NOD) and NOD congenic mice.

Recent Publications :

Junichiro Irie, Brian Reck, Yuehong Wu, Linda S. Wicker, Sarah Howlett, Daniel Rainbow, Eleanor Feingold and William M. Ridgway. Genome wide microarray expression analysis of CD4+ T cells from NOD congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes. The Journal of Immunology, Jan 15;180(2):1071-9. (2008)

Junichiro Irie, Yuehong Wu, Kritika Kachapati, Robert S. Mittler, and William M. Ridgway, Modulating Protective and Pathogenic CD4+ Subsets via CD137 in type one diabetes, Diabetes, 56(1): 186-96 (2007)

Junichiro Irie, Yuehong Wu, Linda S. Wicker, Daniel Rainbow, Michael K. Nalesnik, Raphael Hirsch, Larry Peterson, Patrick S.C. Leung, Chunmei Cheng, Ian Mackay , M. Eric Gershwin, and William M. Ridgway, NOD.c3c4 Congenic Mice Develop Autoimmune Biliary Disease that Serologically and Pathogenetically Models Human Primary Biliary Cirrhosis, The Journal of Experimental Medicine, 203(5):1209-1219 (2006)

Junichiro Irie, Yuehong WU, David A. Sass and William M. Ridgway, Genetic control of anti-Sm antibody production in NOD congenic mice narrowed to the Idd9.3 region. Immunogenetics, p.1-6, Jan, (2006).

Syuichi Koarada, Yuehong Wu, Noreen Fertig, Michael Nalesnik, John A. Todd, Paul A. Lyons, Judith Fenyk-Melody, Linda S. Wicker, Laurence B. Peterson, and William M. Ridgway, Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a non-obese diabetic (NOD) congenic strain. The Journal of Immunology, 173: 2315-2323 (2004)

Syuichi Koarada, Yuehong Wu, Young-Sun Yim, Ward Wakeland, and William M. Ridgway, Nonobese diabetic (NOD) CD4 lymphocytosis maps outside the MHC locus on chromosome 17. Immunogenetics 56:333-337 (2004)

"));