Randy Seeley, PhD
Pathology & Lab Med
Donald C. Harrison Endowed Professor
Director, UC/CCHMC Center of Excellence in Obesity and Diabetes
RCE 312
2170 E. Galbraith Rd
Reading OH 45215
Research Summary
Dr. Seeley's work has focused on the actions of various peripheral hormones in the CNS that serve to regulate food intake, body weight and the regulation of circulating fuels. In particular, he has focused upon the numerous hypothalamic and G.I. peptides and their associated receptors that influence both energy intake as well as peripheral metabolic processes.
Selected Publications
Dr. Seeley has published over 150 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience Reviews, The Journal of Clincial Investigation and the New England Journal of Medicine. He is also the author of 12 book chapters and co-edited a volume on macronutrient selection. He also is the recipient of the 2003 Lilly Scientific Achievement award from the North American Association for the Study of Obesity given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree.
Barrera JG, Jones KR, Herman JP, D'Alessio DA, Woods SC, Seeley RJ. (2011). Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like Peptide-1 loss of function. Journal of Neuroscience, 31, 3904-3913. PMID: 21389245
Ryan K.K., Li, B., Grayson, B.E., Matter, E.K., Woods, S.C. and Seeley, R.J. (2011). A role for central nervous system PPAR-γ in the regulation of energy balance. Nature Medicine. 17, 623-626. PMID: 21532595
Seeley RJ, Sandoval DA. (2011). Weight loss through smoking. Nature, 475, 176-177. PMID: 21753841
Chambers AP, Jessen L, Ryan KK, Sisley S, Wilson-Pérez HE, Stefater MA, Gaitonde SG, Sorrell JE, Toure M, Berger J, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA. (2011). Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats. Gastroenterology. PMID: 21699789
Stefater MA, Sandoval DA, Chambers AP, Wilson-Pérez HE, Hofmann SM, Jandacek R, Tso P, Woods SC, Seeley RJ. (2011). Sleeve Gastrectomy in Rats Improves Postprandial Lipid Clearance by Reducing Intestinal Triglyceride Secretion. Gastroenterology. PMID: 21699773
Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ. (2011). GLP-1 and energy balance: an integrated model of short-term and long-term control. Nature Review Endocrinology. PMID: 21647189