Tso
Patrick Tso , PhD
Pathology & Lab Med-North
Professor
GRI-A271
2120 E. Galbraith Rd
Reading OH 45215
(513)558-2151
Research Summary
One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine. The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology. We are currently studying how bile salts are involved in the absorption of lipids. In addition, we are also studying the factors regulating the synthesis and secretion of apolipoproteins by the small intestine. The apolipoproteins we are studying are: apo AI, apo AIV, apo B, and apo CIII.
Selected Publications
Clegg DJ, Gotoh K, Kemp C, Wortman MD, Benoit SC, Brown LM, D'Alessio D, Tso P, Seeley RJ, Woods Consumption of a high-fat diet induces central insulin resistance independent of adiposity. SC.Physiol Behav. 2011 Jan 15. (in press)
McNamara RK, Jandacek R, Rider T, Tso P. Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats. Eur J Pharmacol. 2011 Feb 10;652(1-3):152-6.
Kohan AB, Qing Y, Cyphert HA, Tso P, Salati LM.Chylomicron remnants and nonesterified fatty acids differ in their ability to inhibit genes involved in lipogenesis in rats. J Nutr. 2011 Feb;141(2):171-6.
Kindel TL, Martins PJ, Yoder SM, Jandacek RJ, Seeley RJ, D'Alessio DA, Obici S, Tso P. Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. Obesity (Silver Spring). 2011 Feb;19(2):380-7.
Warnakula S, Hsieh J, Adeli K, Hussain MM, Tso P, Proctor SD. New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to lower cardiovascular disease risk. Can J Cardiol. 2011 Mar-Apr;27(2):183-91. Review.
Clegg DJ, Gotoh K, Kemp C, Wortman MD, Benoit SC, Brown LM, D'Alessio D, Tso P, Seeley RJ, Woods SC. Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav. 2011 Apr 18;103(1):10-6.
Shen L, Wang DQ, Tso P, Jandacek RJ, Woods SC, Liu M. Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus. Physiol Behav. 2011 Apr 22.
Tso P, Culyer AJ, Brouwers M, Dobrow MJ. Developing a decision aid to guide public sector health policy decisions: A study protocol. Implement Sci. 2011 May 10;6:46.