Cardiovascular & Lipid Disorders

David Askew

Patrick Tso , PhD

Pathology & Lab Med-North

Professor

Research Summary

One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine. The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology. We are currently studying how bile salts are involved in the absorption of lipids. In addition, we are also studying the factors regulating the synthesis and secretion of apolipoproteins by the small intestine. The apolipoproteins we are studying are: apo AI, apo AIV, apo B, and apo CIII.

Recent Publications

Jandacek RJ, Rider T, Keller ER, Tso P. The effect of olestra on theabsorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4'tetrachlorobiphenyl; and perfluorooctanoic acid. Environ Int. 2009 Jul 16. [Epub ahead of print] PubMed PMID: 19616301.

Yoder SM, Yang Q, Kindel TL, Tso P. Stimulation of incretin secretion bydietary lipid: is it dose dependent? Am J Physiol Gastrointest Liver Physiol.2009 Aug;297(2):G299-305. Epub 2009 Jun 11. PubMed PMID: 19520739.

Kindel TL, Yoder SM, Seeley RJ, D'Alessio DA, Tso P. Duodenal-JejunalExclusion Improves Glucose Tolerance in the Diabetic, Goto-Kakizaki Rat by aGLP-1 Receptor-Mediated Mechanism. J Gastrointest Surg. 2009 May 12. [Epub ahead of print] PubMed PMID: 19488823.

Kindel TL, Yang Q, Yoder SM, Tso P. Nutrient-driven incretin secretion intointestinal lymph is different between diabetic Goto-Kakizaki rats and Wistarrats. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G168-74. Epub 2008Dec 4. PubMed PMID: 19056762; PubMed Central PMCID: PMC2643916.

Jandacek RJ, Rider T, Yang Q, Woollett LA, Tso P. Lymphatic and portal veinabsorption of organochlorine compounds in rats. Am J Physiol Gastrointest LiverPhysiol. 2009 Feb;296(2):G226-34. Epub 2008 Dec 4. PubMed PMID: 19056760; PubMed Central PMCID: PMC2643918.

McNamara RK, Able J, Jandacek R, Rider T, Tso P. Gender differences in raterythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. Psychoneuroendocrinology. 2009May;34(4):532-9. Epub 2008 Nov 28. PubMed PMID: 19046819; PubMed Central PMCID:PMC2692269.

 

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